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Cefotaxime Sodium for injection

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  • Cefotaxime Sodium for injection
  • Supplier - CYGNUS HEALTH CARE SPECIALITIES PVT LTD
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  • Mr.Ganesan Subramanian
  • 91-22-32975174
Post Date : August 18
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Other
Mumbai
CYGNUS
Injections
Maharashtra India
As Per Requirement
L/C,T/T

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leading manufaturer and exporter of Pharmacutical Formulations, Oncology products,Anti cancer Medicines CEPHALOSPORINS

Committed to provide our customers with generic versions of popular branded pharmaceuticals and generic drugs that are produced under internationally recognized quality standards in world class manufacturing facilities.
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Vinorelbine Tartrate

Vinorelbine Tartrate

Vinorelbine Tartrate

Vinorelbine tart rate Injection is for intravenous administration.

Description:

Vinorelbine tart rate Injection is for intravenous administration. Each vial contains vinorelbine tart rate equivalent to 10 mg (1-mL vial) or 50 mg (5-mL vial) vinorelbine in Water for Injection, USP. No preservatives or other additives are present. The aqueous solution is sterile and nonpyrogenic.

Vinorelbine tart rate is a semi-synthetic vinca alkaloid with antitumor activity. The chemical name is 3’,4’-didehydro-4’-deoxy-C’-norvincaleukoblastine [R-(R*,R*)-2,3-dihydroxybutanedioate (1:2)(salt)]. 

 

Vinorelbine tart rate is a white to yellow or light brown amorphous powder with the molecular formula C45H54N4O8·2C4H6O6 and molecular weight of 1079.12. The aqueous solubility is >1,000 mg/mL in distilled water.The pH of Vinorelbine Injection is approximately 3.5.

Clinical Pharmacology:

Vinorelbine is a vinca alkaloid that interferes with microtubule assembly. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. Unlike other vinca alkaloids, the catharanthine unit is the site of structural modification for vinorelbine. The antitumor activity of vinorelbine is thought to be due primarily to inhibition of mitosis at metaphase through its interaction with tubulin. Like other vinca alkaloids, vinorelbine may also interfere with: 1) amino acid, cyclic AMP, and glutathione metabolism, 2) calmodulin- dependent Ca++-transport ATPase activity, 3) cellular respiration, and 4) nucleic acid and lipid biosynthesis. In intact tectal plates from mouse embryos, vinorelbine, vincristine, and vinblastine inhibited mitotic microtubule formation at the same concentration (2 µM), inducing a blockade of cells at metaphase. Vincristine produced depolymerization of axonal microtubules at 5 µM, but vinblastine and vinorelbine did not have this effect until concentrations of 30 µM and 40 µM, respectively. These data suggest relative selectivity of vinorelbine for mitotic microtubules.

Indications And Usage:

Vinorelbine is indicated as a single agent or in combination with cisplatin for the first-line treatment of ambulatory patients with unresectable, advanced nonsmall cell lung cancer (NSCLC). In patients with Stage IV NSCLC, Vinorelbine is indicated as a single agent or in combination with cisplatin. In Stage III NSCLC, Vinorelbine is indicated in combination with cisplatin.

Contraindications:

Administration of Vinorelbine is contraindicated in patients with pretreatment granulocyte counts <1,000 cells/mm3

Warning: Vinorelbine should not be used in pregnancy,lactation and in pediatrics..

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Bleomycin

Bleomycin

Bleomycin

Bleomycin is a glycopeptide antibiotic produced by the bacterium Streptomyces verticillus. Bleomycin refers to a family of struc

Bleomycin is a glycopeptide antibiotic produced by the bacterium Streptomyces verticillus. Bleomycin refers to a family of structurally related compounds. When used as an anti-cancer agent, the chemotherapeutical forms are primarily bleomycin A2 and B2. It works by causing breaks in DNA. The drug is used in the treatment of Hodgkin lymphoma squamous cell carcinomas, and testicular cancer, as well as in the treatment of plantar warts and as a means of effecting pleurodesis.

Mechanism of action

Bleomycin acts by induction of DNA strand breaks.Some studies suggest that bleomycin also inhibits incorporation of thymidine into DNA strands. DNA cleavage by bleomycin depends on oxygen and metal ions, at least in vitro. It is believed that bleomycin chelates metal ions (primarily iron) producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. In addition, these complexes also mediate lipid per oxidation and oxidation of other cellular molecules.

Side effects

The most serious complication of bleomycin is pulmonary fibrosis and impaired lung function. It has been suggested that bleomycin induces sensitivity to oxygen toxicity[5] and recent studies support the role of the proinflammatory cytokines IL-18 and IL-1beta in the mechanism of bleomycin-induced lung injury.[6] Past history of treatment with bleomycin should therefore always be disclosed to the anaesthetist prior to undergoing a procedure requiring general anaesthesia.

Other side effects include fever, rash, dermatographism, hyperpigmentation, alopecia (hair loss) and Raynaud's phenomenon (discoloration of fingers and toes).

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