Primary open angle glaucoma with good intraocular pressure lowering effect.
Generic name: Timolol male ate eye drops
English name: Timolol male ate Eye Drops
Pinyin: Malaisuan Saimaluo'er Diyanye
Main components of this product timolol male ate, Excipients: thimerosal.
Chemical name: (a) -1-- (Boc-amino) -3-- [(4 - morpholinyl -1,2,5 - thiadiazole -3---yl) oxy] -2-- propanol maleic chem.
Molecular formula: C13H24N4O3S • C4H4O4
This product is colorless and transparent liquid.
Primary open angle glaucoma with good intraocular pressure lowering effect. For some of the secondary glaucoma, ocular hypertension, some of primary angle-closure glaucoma as well as other drugs and surgery invalid glaucoma, eye drops using this additional IOP lowering effect can be further enhanced.
(1) 5ml: 25mg (2) 5ml: 12.5mg
Eye drops. 1 drop once a day 1 or 2 times, such as intraocular pressure control, to day 1. If the original use of other drugs, change the FDA in the treatment, not easy to suddenly disable the original drugs, the FDA shall drop from the phasing out of the day.
1, the most common adverse reactions are ocular burning and stinging.
2, Cardiovascular System: bradycardia, and cardiac arrhythmias.
3, the nervous system: dizziness, increased symptoms of myasthenia gravis, paresthesia, somnolence, insomnia, nightmares, depression, mental confusion, hallucinations.
4 Respiratory System: bronchospasm, respiratory failure, dyspnea, nasal congestion, coughing, upper respiratory tract infection.
5, the endocrine system: hide diabetes or insulin hypoglycemia after hypoglycemic agents.
1, bronchial asthma, or have a history of bronchial asthma, severe chronic obstructive pulmonary disease.
2, sinus bradycardia, or degree atrioventricular block, was heart failure, cardiogenic shock.
3, those who are allergic to the chemicals.
One, when shortness of breath and pulse slowed down, allergy symptoms, immediately stop using the product.
2, the use of cerebral circulation insufficiency in the event of symptoms should be immediately discontinued.
3, cardiac dysfunction, the FDA should avoid taking calcium antagonists.
4, no history of heart failure patients, such as heart failure symptoms should immediately stop there.
5, catecholamine depletion taking drugs (such as reserpine) who, using the product should be closely observed.
6, coronary artery disease, diabetes, hyperthyroidism and myasthenia gravis patients, the FDA needs eye drops prescribed time.
7, this product be used with caution in patients with spontaneously low blood glucose and insulin or oral hypoglycemic patients, because of β-blockers can mask hypoglycemia.
8, the product easy to separate for the treatment of angle-closure glaucoma.
9, in combination with other eye drops, please interval of 10 minutes.
Of 10, regular review of intraocular pressure, intraocular pressure adjustment of medication according to the program.
11, should be shaken before use to avoid contact with eyes and tip the container to prevent the eye drops pollution.
Pregnant and lactating women drug
This product is for the safety of pregnant women has not been determined. After drops of milk in lactating women measured in this product, because of the nursing infant has a variety of potential adverse reactions, to be based on the importance of the mother drops the FDA decided to terminate nursing or discontinue medication.
The goods for children's safety and efficacy has not been determined.
Not to proceed with the test and no reliable reference.
1, and epinephrine combination can cause the pupil to expand.
2, not in favor of two kinds of local application of β blocker at the same time.
3, this product combined with the calcium channel blocker should be careful because they can cause atrioventricular block, left ventricular failure, and hypotension. Patients with impaired heart function, combined use of two drugs should be avoided.
4, catecholamine depletion are taking drugs (such as reserpine not), so the FDA should be closely observed, as can cause significant hypotension and bradycardia.
5, the product with digitalis and calcium channel blocker combination may further extend the AV conduction time.
6, this product combined with Kuining Ding can cause heart rate and other systemic side effects of β blockers. Possible reason is Kuining Ding inhibit P450 enzymes and CYPZD 6 metabolism of timolol.
Excessive application of a similar product can cause systemic side effects of β receptor blockers, such as dizziness, headache, shortness of breath, bradycardia, bronchospasm and cardiac arrest.
Pharmacological effects: Timolol male ate is a non-selective β-adrenergic receptor blockers, there is no obvious endogenous local anesthetic to be sympathetic activity and effect on myocardial no direct inhibitory effect. The product of timolol male ate eye drops, intraocular pressure of patients and controls had high intraocular pressure lowering effect. Reduce the intraocular pressure of its exact mechanism is not clear, intraocular pressure tracings and aqueous fluorophotometry study suggests that lowering intraocular pressure of the goods and the reduction of aqueous formation related.